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As a synthetic 39-amino acid peptide, Retatrutide (LY3437943) acts as a single-sequence multi-agonist with structural affinity for three distinct metabolic receptors: Gastric Inhibitory Polypeptide (GIP), Glucagon-Like Peptide-1 (GLP-1), and Glucagon (GCGR)
These metabolic differences are generally modest compared to the dramatic difference in total weight loss
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Mutations in other genes of this pathway (e.g., LEPR , POMC ) also cause monogenic obesity, but the efficacy of bariatric surgery in these patients differs from that in MC4R -deficient patients
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