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Side effect awareness There is, of course, an elephant in the room

10.1097/prs.0000000000009866 18 BrownS.KokosisG.GrazianoF

Only 4.2% of participants discontinued due to side effects after week 24, indicating that side effects become manageable or resolve entirely for the vast majority who continue treatment

Variants S463D and S463K of EcGGT showed no detectable activities with considerable maturational defects (Hsu et al., 2009), while S463T mutant displayed 40% loss in activity without affecting autoprocessing, indicating that presence of hydroxyl group is required for autoprocessing and addition of charged residues at this position is detrimental for both processing and activity

Once treatment begins, establish a simple tracking system: note the date your medication arrives and set a calendar reminder for day 28