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On the contrary, the Peripherally Acting Opioid Receptor Antagonists (PAMORAs) are developed to selectively block peripherally located opioid receptors, with minimal effects on the centrally mediated analgesic properties (36)

In 2021, it has been reported a case of a woman with a past history of intravenous drug abuse on opioid substitution treatment with buprenorphine

Clean wound and apply sterile dressing