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This mechanism produces expected side effects: nausea, vomiting, constipation, and reduced appetite occur most often in the first 4 weeks as the body adjusts to altered digestive signaling

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24,188190 In diabetic patients, an increase in filtered glucose of renal proximal tubule was found to enhance SGLT-2 activity, which subsequently worsened glycemic control and promoted Na + loading following impaired blood pressure control