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patient in intramuscular arm provide appointments for injections Visit 2 (week 8) Anamnesis: record lifestyle habits and use of alcohol Symptoms: if pathological at the first visit, record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: if pathological at the first visit examine for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Request analyses to be performed one week before next visit: haemogram and serum vitamin B12 Questionnaires: EuroQoL-5D Assessment of adverse effects Therapeutic plan: patient in oral arm provision of medication