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The first GLP-1RA was discovered in the Gila monster, a desert-dwelling lizard capable of consuming up to half its body weight in a single meal while maintaining stable blood glucose levels

GLP-1 drugs are glucose-dependent

All the included drugs are administered by injection, except for Rybelsus, which is taken as a pill

Additionally, many health insurance plans are beginning to cover GLP-1 medications, making them more accessible to patients

Novo was first-to-market with GLP-1s, but has failed to reassure investors about the drugs brand strength or convince doctors that Wegovy is better than Zepbound for weight loss