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The m-MITF isoform is uniquely expressed in the melanocyte lineage and is subject to cAMP-mediated signal regulation of expression downstream of MC1R, the receptor whose loss of function is associated with red hair and pale skin (phototype 1) 2

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The 2019 suit centered on billionaire investor Edwin Lamperts role in liquidating a poorly performing segment of SHOS and replacing two directors with those less likely to oppose him

CHAC1 demonstrates higher catalytic efficiency and is upregulated during development or in response to stress

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