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IL-17 has extensive pro-inflammatory properties on the induction of cytokine G-CS (responsible for recruitment of neutrophils) and IL-22 (which stimulates mucins, fibrinogen, anti-apoptotic proteins, and serum amyloid A) [102]

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Nat Med 21:506511 Stepensky D, Friedman M, Raz I, Hoffman A (2002) Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect

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Manageable adjustments

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The changes observed at week 68 from STEP 1 trial were assumed to be maintained for total cholesterol and HDL change as assessment of these risk factors was not performed at this time point

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