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These findings suggest that 4-HNE may play a role in the early stages of melanoma tumorigenesis, while its loss in metastases may be associated with the increased proliferative activity of metastatic cells [112]

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The mechanism involves activating the pituitary gland through pathways like protein kinase C (PKC) and phospholipase C (PLC), which promotes the release of growth hormone (GH) into the bloodstream