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These medications work primarily by: Activating GLP-1 receptors in the brain to reduce appetite and increase satiety Slowing gastric emptying to prolong feelings of fullness Improving insulin secretion and reducing glucagon release Modulating reward pathways related to food intake None of these mechanisms require an intact gallbladder to function effectively

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A balanced microbiome appears to be essential for healthy brain function, while microbial perturbations can contribute to cognitive deficits, mood disturbances, and neuroinflammation (Sorboni et al., 2022)