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These results highlight that pancreatic beta-cell dysfunction with respect to GLP-1 can exacerbate glucose intolerance and play a role in the progression of chronic conditions associated with impairments in glucose homeostasis, such as type 2 diabetes mellitus(T2DM)

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TMAO is unreliable as a standalone biomarker due to the significant influence and variability of liver function, diet, gut microbiota diversity, and genetic factors