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Physicians should screen for conditions like depression before prescribing the drugs, the researchers said

10.1016/j.phrs.2009.06.004 140

What studies show: People can lose ~15% of their body weight on average with semaglutide The catch: Once the drug is stopped, weight regain is common most people regain much of their lost weight within a year

2.8% for 16 months, and 1.4% for 18 months

lifetime decreased medical expense $62K JAMA Health Forum (2025): Showed that the cost per quality adjusted life year (QALY) for tirzepatide (Zepbound) was $197K and the cost per QALY for semaglutide (Wegovy) was $468K