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The generalizability of findings is also often limited by insufficient consideration of individual differences, such as genetic background, baseline nutritional status, gut microbiota composition, and specific OA phenotypes (e.g., metabolic vs

Graham et al

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Significantly, melatonin supplementation has demonstrated the capacity to alleviate oxidative stress and impede the accumulation of A, as well as tau hyperphosphorylation, in the hippocampus of aged rats exhibiting brain insulin resistance induced by a high-fat diet [135]

Because interaction data is sparse, underreported, and largely confined to preclinical rodent models