Patients with severe neurological complications from SARS-CoV-2 infection have an increased CSF Q-albumin ratio indicating BBB disruption, coupled with elevated CSF proteins, such as IL-8, which are associated with BBB disruption 65
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Laboratory studies using animal models have explored mechanisms including angiogenesis (new blood vessel formation), modulation of inflammatory pathways, and cellular processes in tendons, ligaments, muscles, and connective tissues
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