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Based on Phase 2 trial data (Jastreboff et al., NEJM , 2023), the most commonly reported adverse effects of retatrutide include: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (most frequent, particularly during dose escalation) Injection site reactions: Redness, bruising, or mild discomfort Decreased appetite: Generally considered a therapeutic effect but can contribute to nutritional deficiency if severe Increased heart rate: Observed with glucagon receptor agonism
The study provided evidence at 12 weeks that patients in the GLP-1 group acquired better scores in all cognitive tests and showed remarkable improvement in memory and attention ( P = .040) tests compared with the control group after multivariable adjustment
Semaglutide should not be used if you or any family members have had medullary thyroid carcinoma (MTC), or if you have a condition known as Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
No antibiotic is universally contraindicated with semaglutide, but your healthcare provider should carefully weigh benefits and risks for your specific infection before prescribing these classes
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