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The flip side is that the long half-life also creates relatively stable medication levels between doses, which can actually reduce side effect intensity compared to medications with more dramatic peaks and troughs

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When Stopping GLP-1 Therapy May Be Medically Necessary Certain clinical situations warrant stopping GLP-1 medications despite rebound risk: medullary thyroid cancer history or family predisposition, severe pancreatitis, personal history of thyroid malignancy, or severe allergic reaction