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In addition to GSH inhibition, LCS3 is reported to inhibit the activity of thioredoxin reductase1 (TXNRD1), a critical antioxidant regulator maintaining the redox state of thioredoxin (TRX) [19](Supplementary Fig

10.1053/j.semperi.2018.05.007 47 JiL.JiangP.LuB.ShengY.WangX.WangZ

Proc Natl Acad Sci U S A 107:74197424