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Future Directions: Precision Medicine Through Bioinformatics As orforglipron moves toward potential FDA approval (expected 2025-2026), bioinformatics will continue to shape its clinical implementation

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Commonly discussed effects include: Nausea Constipation Diarrhea Fatigue Bloating headache These effects are often mentioned more frequently during early dosage increases

Interestingly, within the drugs tested were other GLP-1RAs such as exenatide or liraglutide

A role for genetic has been demonstrated, with evidence of an increased risk of NAFL in patients with polymorphisms, like those associated to patatin-like phospholipase domain containing 3 (PNPLA3) rs738409, transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 and membrane bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 (4447)