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Gastrointestinal medications may interact with tirzepatide through various mechanisms

One to be wary of is having a certain taste in your mouth

For a deeper look at the side-effect picture, our guide to GLP-1 side effects in 2026 is a helpful companion read

Pregnancy and Breastfeeding: Semaglutide is not recommended for use during pregnancy or while breastfeeding

Eighteen studies examined the effect of GLP-1RAs on weight loss, glucose control and mental illness outcomes in adults with a severe mental disorder, such as major depressive disorder, bipolar effective disorder, schizophrenia spectrum disorders, and alcohol use disorder