Were here to help you lose fat, not just weight, and more importantly, keep it off
TL;DR: The GLP-1 receptor agonist landscape in 2026 spans four distinct compounds: semaglutide (selective GLP-1 RA, MW 4113.58 Da, injectable and oral), tirzepatide (dual GLP-1/GIP agonist, MW 4813.45 Da), retatrutide (triple GLP-1/GIP/glucagon agonist, MW ~4500 Da, Phase 3), and orforglipron (non-peptide oral GLP-1 agonist, MW 541.65 Da, FDA-approved April 2026)
Initial management involves confirming the heart rate elevation through repeated measurements and excluding other contributing factors
Garrison RJ, Wilson PW, Castelli WP, Feinleib M, Kannel WB, McNamara PM
The most successful results often happen when you pair GLP-1 support with a well-organized plan