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In a retrospective study, Saud Alawad, MBBS, third-year internal medicine resident at West Virginia University, and colleagues analyzed adults with a group 1 PAH diagnosis between January 2013 and December 2021 from the TriNetX database to determine how GLP-1 receptor agonist use (n = 1,714) impacts all-cause mortality, respiratory failure, atrial fibrillation, right heart failure and ED visits vs
Abbreviations Akt: Protein kinase B BMI: Body mass index cAMP: Cyclic adenosine monophosphate CGRP: Calcitonin gene-related peptide DM: Diabetes mellitus DPP: 4-dipeptidyl peptidase-4 GLP: 1-glucagon-like peptide-1 GLP: 1R-glucagon-like peptide-1 receptor HbA1c: Glycated hemoglobin IGF: Insulin-like growth factor MAPK: Mitogen-activated protein kinase mTOR: Mammalian target of rapamycin NF: B-nuclear factor B PI3K: Phosphoinositide 3-kinase PKA: cAMP-dependent protein kinase SGLT: 2-sodium-glucosecotransporter-2 T2DM: Type 2 diabetes mellitus References Iijima, T., Shibuya, M., Ito, Y., & Terauchi, Y
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