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GST catalyzes the conjugation of cytotoxic agents to glutathione (-glutamyl-cysteinyl-glycine), producing less reactive chemical species

For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

In addition, demographic diversity is not mentioned in most of the studies, which may affect the applicability of the findings to various populations

theyre reshaping the entire food value chain.

Med Sci Sports Exerc 45(7):12691276