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These picomolar levels of 15-HpETE-PE alone (Supplemental Figure 4A, generated under IL-13 plus arachidonic acid conditions) would be insufficient to directly oxidize the nanomolar changes caused by oxidation of GSH to GSSG observed in response to IL-13 (or the change with inhibition of 15LO1 or KD of ALOX15 /15LO1)
30-Second Takeaway Supplementing with glutathione, an antioxidant that neutralizes free radicals, is generally safe
It also helps to boost the production of other antioxidants such as vitamin C and E
[DOI] [PMC free article] [PubMed] [Google Scholar] Li ZS, Schmauss C, Cuenca A, Ratcliffe E, Gershon MD (2006) Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice
NAD+ and glutathione have different cellular functions, locations, mechanisms of action, and therapeutic applications, though both decline substantially with age
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