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Among the rather long list of their predecessors, the authors mentioned Mortimer Louis Anson (19011968) and Alfred Ezra Mirsky (19001974), who, in 1934, reported that denatured hemoglobin can be digested by trypsin, which does not attack the native protein ( However, the actual father of limited proteolysis as a research tool was Kaj Ulrik Linderstrm-Lang, who, together with Martin Ottesen, coined the term in 1949, to differentiate the restricted specificity of certain enzymes under certain conditions from the random proteolysis accompanying total protein degradation (Linderstrm-Lang and Ottesen, 1949)

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Meal composition is one factor that influences satiety

683 Intermittent fasting (IF) has been reported to reduce lipid peroxidation and mitochondrial dysfunction, and one month of IF increased the expression of protective GPX4, partially eliminated the ferroptosis of cortical neurons induced by TBI, and helped to alleviate cognitive impairment

Therefore, choline is also an important substance for fat metabolism