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For the Sprague Dawley study, rats were single housed and had ad libitum access to a chow diet, kaolin pellets (K50001, Research Diets) and tap water

These hormonal elevations in response to RE take place in a unique physiological environment, whereby acute elevations in circulating blood hormone concentrations, resulting from a combination of either e.g., increased secretion, reduced hepatic clearance, reduced plasma volume or reduced degradation ratesinteract with receptors on the target tissue cell membranes or with nuclear/cytoplasmic receptors located within the target tissue (e.g., steroid receptors)

Product-specific titration instructions come from the current prescribing information

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions