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Prolonged supersaturation of uric acid leads to the formation and deposition of monosodium uric acid crystals, which eventually develop into obstructive nephropathy, kidney stones, and gout [12]

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When applied regularly, they work at their best

The lethal concentration (LC 50 ) for HThF cells was ~ 1 M, while the LC 50 for the PTC cell lines was substantially less (0.050.5 M)