In the case of severe DNA damage, PARP1 drives apoptosis through p53 activation under normal conditions
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Moreover, the way GSH depletion can lead to immune system failure and make the end organs in danger of oxidative stress-mediated damage needs to be explained
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These enzymes catalyze the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid [249]
