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TNF inhibitor adalimumab reduces TNF-activated phosphorylation of serine 536 residues in NF-B p65, with degradation of inhibitor of B (IB, and the levels of TNF and interleukin-6 (IL6) expression in A1-40 induced AD mice [167]

In the same study, glutamic pyruvate transaminase was five-fold higher in periportal hepatocytes versus centrilobular hepatocytes but increased in both areas of the lobule during a three-day fast