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Again, the metabolites identified above do not necessarily reflect the brains cellular processes in isolation, though BBB disruption, limited glymphatic [49] and passive transport to the periphery all increase after TBI [45]

Importantly, the structural features of polysaccharides dictate fermentation kinetics and SCFA profiles, with identical fermentation conditions producing variable SCFA yields (148)

Furthermore, there is concern regarding the proper use of ACS in special populations, such as those with IUGR, maternal diabetes, and chorioamnionitis, due to their independent contributions to neonatal morbidity and their potential to decrease the therapeutic index of ACS (265, 266)

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