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This is consistent with previous studies of the amylin analogue, pramlintide

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Aref'eva, R.P., Zh

Targeting inflammasome activation, inhibiting caspase-1, employing anti-inflammatory agents, and modulating the gut microbiota and bile acid metabolism represent promising avenues for developing novel treatments for this common and potentially life-threatening condition

Depressive-like behavior In male rodents, supplementation with vitamin E (P31-45) [104] or folic acid (P41-61) [41] reversed the POS-induced depressive-like behavior measured in the FST at P6061 [41] and at P45-47 [104], but not in the splash test (ST) at P45-47 [104]