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Semaglutide: Linear polypeptide PEPTIDE SEQUENCE Cagrilintide: ?Glu-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH 2 Semaglutide: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH CHEMICAL STRUCTURE Cagrilintide: Semaglutide: CHEMICAL STRUCTURE Cagrilintide: C 194 H 312 N 54 O 59 S 2 Semaglutide: C 187 H 291 N 45 O 59 Mechanism of Action Cagrilintide acts primarily as a long-acting amylin analogue, stimulating amylin and calcitonin receptors to promote satiety, slow gastric emptying, and suppress postprandial glucagon release

Let it trickle down the glass wall toward the powder rather than jetting directly onto the lyophilized material