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In the subsequent phase III STEP trials of semaglutide, 2.4 mg once weekly, carefully up-titrated over 20 weeks, average weight losses of up to 18% were achieved over 68 weeks in people with obesity (start weight 107 kg) [40]

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Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents

The formulation also includes a phosphate buffer system and a preservative to keep the pH within a physiologically acceptable range

Su mdico puede volver a aumentar la dosis al cabo de otras 4 semanas en funcin de la respuesta de su organismo a la medicacin