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Clemmensen OJ, Kroon S

EPIDEMIOLOGY AND DISEASE BURDEN OF MASLD/MASH MASLD is estimated to impact around 32.4% of adults across the world and is currently considered the leading chronic liver disease globally, with estimates exceeding one billion individuals affected [13,14]

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Simultaneously, AMPK suppresses the nuclear translocation of sterol regulatory element-binding protein 1c (SREBP1c), downregulating the expression of key lipogenic enzymes such as fatty acid synthase (FASN) and stearoyl-CoA desaturase 1 (SCD1), thereby inhibiting de novo triglyceride (TG) synthesis