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On the basis of these findings, the 20 g OD dose was chosen for the phase III program because it appeared to offer the best efficacy-to-tolerability ratio [10]

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Low GSH in aging is associated with lower intake of GSH precursors, mainly cysteine, and lower GSH synthesis evidencing diminished function of nuclear factor erythroid 2related factor 2 (Nrf2)-dependent inductive mechanisms that enhance glutamate cysteine ligase expression, rate limiting factor for the synthesis of GSH (McCarty and DiNicolantonio, 2015)

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