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Several groups have profiled gene expression in patients with and without COPD or between patients with varying levels of airflow obstruction in order to understand differences in gene expression related to COPD [611]

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MGCA1 can be distinguished from the other forms of MGCA because the levels of 3-methylglutaconic acid are highly elevated, whereas levels of methylglutaric acid are usually only slightly elevated, and there is a high level of 3-hydroxyisovaleric acid excretion which is not seen in the other forms of MGCA