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According to one study, the most common side effects are gastrointestinal issues, including: Nausea Vomiting Diarrhea Abdominal pain Rare, but more serious side effects can include allergic reactions, thyroid tumors, and pancreatitis (inflammation of the pancreas)

Betaine has been shown to suppress the expression of proinflammatory cytokines such as TNF- and IL-6 via inhibition of the NLRP3 inflammasome pathway, thereby attenuating hepatic inflammation

During the first few weeks, your neurons may actually reduce their sensitivity to serotonin as a protective mechanism