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Participants taking semaglutide showed significant reductions in major cardiovascular events, including heart attack and stroke, compared to placebo

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Research-grade Melatonin (N-acetyl-5-methoxytryptamine), an endogenous indoleamine produced by the pineal gland, is designed for controlled in-vitro and preclinical investigations of circadian rhythm regulation, ROS/RNS scavenging mechanisms, antioxidant defense pathways, mitochondrial protection, and neuroendocrine signaling

2 Methodology The research protocol for this study was registered with the International Prospective Register of Systematic Reviews (PROSPERO) with registration number CRD420251157476

Continuous variables are presented as mean standard deviation or median (interquartile range) based on distribution, while categorical variables are expressed as frequencies (percentages)