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Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

For the rotarod experiments, we used six to eight animals per condition

Change at the Same Time: For improved symptom monitoring, replace your adhesive at the same time of day each occasion

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It also flags older patients and those with altered metabolism as more likely to accumulate drug exposure