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While safe, it should still be used at the lowest dose possible and for the shortest duration necessary

However, the isoform A (exon 11-splice variant) of IR (IR-A), normally expressed in fetal tissues, promotes cell growth in response to IGF-2 stimulation and has been reported to be abundantly expressed in some IGF-1R deficient leiomyosarcomas (Sciacca et al, 2002)

Second, epidemiological studies indicating a reduced risk of dementia are susceptible to residual confounding factors, such as healthy user bias and treatment selection effects

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