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It's essential for maintaining optimal brain function, supporting a strong immune system, and promoting healthy aging

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The trial enrolled 806 participants across the US, including Puerto Rico, Argentina and Brazil to a lead-in period with intensive lifestyle intervention

For RCTs, this included assessment of: (1) risk of bias (via Cochrane RoB 2 tool), (2) inconsistency of results across studies, (3) indirectness of evidence, (4) imprecision due to sample size or confidence intervals, and (5) potential publication bias