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doi: 10.1007/164_2020_388 121 WatanabeSMoniagaCSNielsenSHara-ChikumaM

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Nrf2 Activation: In response to oxidative stress, Nrf2 activates the transcription of genes involved in antioxidant defense, including those involved in the synthesis of glutathione

Micronized progesterone, which more closely mirrors the molecular structure of the body's own progesterone, has largely replaced the older synthetic progestins used in the original WHI trial, and appears to offer improved tolerability and a more favorable safety profile [11,27]

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