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The presence of GLP-1 receptors in testicular tissue and evidence of direct, weight-loss-independent effects on sperm function raises the possibility that GLP-1 drugs may act on male reproductive biology through two distinct mechanisms simultaneously: one systemic (through metabolic improvement) and one local (through direct testicular signaling)

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The slowed movement of food through the digestive system can lead to feelings of excessive fullness (early satiety), discomfort, and in some cases, nausea that persists between meals