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High titers of antibody against thyroglobulin (TG) and thyroid peroxidase (TPO) are present in most patients with Hashimoto's thyroiditis(17), and TPO antibodies are complement fixing and may be cytotoxic

GLA-specific single-guide RNA (sgRNA) was prepared to introduce deletion mutations in exon 1 of the GLA gene, as shown in Supplementary Fig

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