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Lancet 397 , 23722384 (2021)

Starting with low concentrations and limited application areas is prudent

Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6

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Genotype should be considered when attempting to predict the potential CYP2C9 drug-drug interactions because of the possible genotype-dependent inhibition (22,23)