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A firm lump at the injection site that persists beyond 48 hours is likely lipohypertrophy fibrous tissue buildup from repeated injections in the same location

Nausea ranged from approximately 11% at the lowest 1 mg dose to 64% in some intermediate-dose arms, with about 33% reported in the 9 mg fixed-dose arm (the highest-efficacy arm)

put forward that the abnormal level of soluble UA in body fluid could augment inflammatory effect through resetting epigenetic reprogramming and immunometabolism of innate immune cells, which was termed as trained immunity (5759)

HRP-conjugated secondary antibody was used to detect the protein with chemiluminescence

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