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At the molecular level, higher GLP-1R levels enhance GIPR responses -arrestin dependently, while higher GIPR levels reduce GLP-1R activity, perhaps providing additional context for how GIPR blockade might augment GLP-1R signaling in cells co-expressing both receptors Cell Chemical Biology by Cell Press GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways cell.com Fascinating work