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Currently, FDA-approved medications for chronic weight management include orlistat, phentermine/topiramate, naltrexone/bupropion, and liraglutide, but they can be expensive and have potential side effects

Just like glycine residues, internal prolines in ACPs are important for conformational flexibility and interaction of the peptide with the membrane (61)

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This in turn can cause a range of neurological and psychiatric problems including, in some cases, changes in mood or energy levels

In the past few years, insight into the mechanisms of leptin resistance has been elucidated