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Unlike injectable obesity drugs, which are peptides designed to mimic the appetite-controlling GLP-1 hormone, orforglipron is a small molecule pill that is easier to manufacture and package, said Kenneth Custer, president of Lilly's cardiometabolic health division

They represent genuine cellular protection during a period of significant physical change

Similarly, another study found a higher rate of progression of proliferative diabetic retinopathy as well as risk of new-onset diabetic macular edema with GLP-1 RAs compared to SGLT-2is

Through these receptors, GLP-1 helps regulate blood glucose, appetite, and body weight

Some wonder: Could GLP-1s offer support where other treatments fall short