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Whereas, some longitudinal studies have noticed a significant decrease in the IMT following a GLP-1-based therapy 14,36 , the present meta-analysis reveals a non-significant decrease in IMT, but this may be because of the less availability of data and paradigmatic and treatment spell deviations, thus necessitates the conduct of more trials with better designs

full long-term data still emerging Not yet approved Pros and cons summarise available published data from peer-reviewed studies

Enhanced AMPA receptor trafficking mediates the anorexigenic effect of endogenous glucagon-like peptide-1 in the paraventricular hypothalamus

Early research suggested it promoted fat storage

And Druckers work in the 1980s and 1990s helped pave the way for key diabetes drugs, like Ozempic