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Therefore, reducing the expression of ACSL4 and LPCAT3 reduces the accumulation of lipid peroxide substrates in cells, thus inhibiting ferroptosis

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Their complementary actions provide a biological rationale for combination therapy

In fact, in GLUTag cells, we showed that L-glutamine enhanced GLP-1 secretion and cAMP accumulation, suggesting that L-glutamine stimulates GLP-1 secretion by activating Gs-coupled receptors such as TAS1R3 28